4ka6
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4ka6| PDB=4ka6 | SCENE= }} | {{STRUCTURE_4ka6| PDB=4ka6 | SCENE= }} | ||
===Structure of D141A variant of B. pseudomallei KatG complexed with INH=== | ===Structure of D141A variant of B. pseudomallei KatG complexed with INH=== | ||
| + | {{ABSTRACT_PUBMED_24568093}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024568093</ref><references group="xtra"/><references/> |
[[Category: Catalase peroxidase]] | [[Category: Catalase peroxidase]] | ||
[[Category: Loewen, P C.]] | [[Category: Loewen, P C.]] | ||
Revision as of 07:38, 2 April 2014
Contents |
Structure of D141A variant of B. pseudomallei KatG complexed with INH
Template:ABSTRACT PUBMED 24568093
Function
[KATG_BURPS] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activity.[1]
About this Structure
4ka6 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Vidossich P, Loewen PC, Carpena X, Fiorin G, Fita I, Rovira C. Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation. J Phys Chem B. 2014 Mar 20;118(11):2924-31. doi: 10.1021/jp4123425. Epub 2014 Mar, 7. PMID:24568093 doi:http://dx.doi.org/10.1021/jp4123425
- ↑ Singh R, Wiseman B, Deemagarn T, Donald LJ, Duckworth HW, Carpena X, Fita I, Loewen PC. Catalase-peroxidases (KatG) exhibit NADH oxidase activity. J Biol Chem. 2004 Oct 8;279(41):43098-106. Epub 2004 Jul 26. PMID:15280362 doi:10.1074/jbc.M406374200
