4nn6
From Proteopedia
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{{STRUCTURE_4nn6| PDB=4nn6 | SCENE= }} | {{STRUCTURE_4nn6| PDB=4nn6 | SCENE= }} | ||
===Cytokine receptor complex - Crystal form 1B=== | ===Cytokine receptor complex - Crystal form 1B=== | ||
| + | {{ABSTRACT_PUBMED_24632570}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4nn6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN6 OCA]. | [[4nn6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN6 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024632570</ref><references group="xtra"/><references/> | ||
[[Category: Savvides, S N.]] | [[Category: Savvides, S N.]] | ||
[[Category: Schie, L van.]] | [[Category: Schie, L van.]] | ||
Revision as of 07:52, 2 April 2014
Contents |
Cytokine receptor complex - Crystal form 1B
Template:ABSTRACT PUBMED 24632570
Function
[TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [CRLF2_MOUSE] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
About this Structure
4nn6 is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol. 2014 Mar 16. doi: 10.1038/nsmb.2794. PMID:24632570 doi:http://dx.doi.org/10.1038/nsmb.2794
