4oz2

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'''Unreleased structure'''
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{{STRUCTURE_4oz2| PDB=4oz2 | SCENE= }}
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===Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole===
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{{ABSTRACT_PUBMED_24616449}}
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The entry 4oz2 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Authors: Vinkovic, M.
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==Function==
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[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>
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Description: Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole
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==About this Structure==
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[[4oz2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ2 OCA].
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==Reference==
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<ref group="xtra">PMID:024616449</ref><references group="xtra"/><references/>
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[[Category: Adenylate cyclase]]
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[[Category: Vinkovic, M.]]
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[[Category: Lyase]]
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[[Category: Protein-ligand complex]]

Revision as of 09:00, 2 April 2014

Template:STRUCTURE 4oz2

Contents

Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole

Template:ABSTRACT PUBMED 24616449

Disease

[ADCYA_HUMAN] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[ADCYA_HUMAN] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.[1] [2]

About this Structure

4oz2 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H. Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket. ChemMedChem. 2014 Feb 24. doi: 10.1002/cmdc.201300480. PMID:24616449 doi:http://dx.doi.org/10.1002/cmdc.201300480
  1. ↑ Geng W, Wang Z, Zhang J, Reed BY, Pak CY, Moe OW. Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1305-16. Epub 2005 Jan 19. PMID:15659711 doi:http://dx.doi.org/10.1152/ajpcell.00584.2004
  2. ↑ Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, Buck J, Levin LR, Conner GE, Fregien N, Salathe M. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol. 2007 Jul;130(1):99-109. PMID:17591988 doi:http://dx.doi.org/jgp.200709784

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