4nue

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'''Unreleased structure'''
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{{STRUCTURE_4nue| PDB=4nue | SCENE= }}
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===Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor===
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{{ABSTRACT_PUBMED_24144283}}
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The entry 4nue is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Plotnikov, A.N., Joshua, J., Zhou, M.-M.
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor
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==About this Structure==
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[[4nue]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUE OCA].
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==Reference==
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<ref group="xtra">PMID:024144283</ref><references group="xtra"/><references/>
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[[Category: Joshua, J.]]
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[[Category: Plotnikov, A N.]]
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[[Category: Zhou, M M.]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Transcription-transcription inhibitor complex]]

Revision as of 09:03, 2 April 2014

Template:STRUCTURE 4nue

Contents

Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor

Template:ABSTRACT PUBMED 24144283

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4nue is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. doi: 10.1021/jm401334s. Epub 2013 Nov 11. PMID:24144283 doi:http://dx.doi.org/10.1021/jm401334s
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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