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4cae
From Proteopedia
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| - | + | {{STRUCTURE_4cae| PDB=4cae | SCENE= }} | |
| + | ===Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)=== | ||
| + | {{ABSTRACT_PUBMED_24641010}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586] | ||
| - | + | ==About this Structure== | |
| + | [[4cae]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAE OCA]. | ||
| - | + | ==Reference== | |
| + | <ref group="xtra">PMID:024641010</ref><references group="xtra"/><references/> | ||
| + | [[Category: Glycylpeptide N-tetradecanoyltransferase]] | ||
| + | [[Category: Brannigan, J A.]] | ||
| + | [[Category: Holder, A A.]] | ||
| + | [[Category: Leatherbarrow, R J.]] | ||
| + | [[Category: Rackham, M D.]] | ||
| + | [[Category: Rangachari, K.]] | ||
| + | [[Category: Tate, E W.]] | ||
| + | [[Category: Wilkinson, A J.]] | ||
| + | [[Category: Benzothiophene]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Malaria]] | ||
| + | [[Category: Myristoylation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 09:12, 2 April 2014
Contents |
Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)
Template:ABSTRACT PUBMED 24641010
Function
[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
About this Structure
4cae is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP). J Med Chem. 2014 Mar 27;57(6):2773-88. doi: 10.1021/jm500066b. Epub 2014 Mar 18. PMID:24641010 doi:http://dx.doi.org/10.1021/jm500066b
