4cae

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Revision as of 07:09, 16 October 2013 (edit) OCA (Talk | contribs) m (Protected "4cae" [edit=sysop:move=sysop]) ← Previous diff		Revision as of 09:12, 2 April 2014 (edit) (undo) OCA (Talk | contribs) Next diff →
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-	'''Unreleased structure'''	+	{{STRUCTURE_4cae| PDB=4cae | SCENE= }}
		+	===Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)===
		+	{{ABSTRACT_PUBMED_24641010}}
-	The entry 4cae is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
-	Authors: Rackham, M.D., Brannigan, J.A., Rangachari, K., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.	+	==About this Structure==
		+	[[4cae]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAE OCA].
-	Description: Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)	+	==Reference==
		+	<ref group="xtra">PMID:024641010</ref><references group="xtra"/><references/>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Brannigan, J A.]]
		+	[[Category: Holder, A A.]]
		+	[[Category: Leatherbarrow, R J.]]
		+	[[Category: Rackham, M D.]]
		+	[[Category: Rangachari, K.]]
		+	[[Category: Tate, E W.]]
		+	[[Category: Wilkinson, A J.]]
		+	[[Category: Benzothiophene]]
		+	[[Category: Inhibitor]]
		+	[[Category: Malaria]]
		+	[[Category: Myristoylation]]
		+	[[Category: Transferase]]

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Revision as of 09:12, 2 April 2014

Template:STRUCTURE 4cae

Contents 1 Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b) 2 Function 3 About this Structure 4 Reference

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)

Template:ABSTRACT PUBMED 24641010

Function

[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]

About this Structure

4cae is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

• Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP). J Med Chem. 2014 Mar 27;57(6):2773-88. doi: 10.1021/jm500066b. Epub 2014 Mar 18. PMID:24641010 doi:http://dx.doi.org/10.1021/jm500066b