This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4nud

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4nud" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4nud| PDB=4nud | SCENE= }}
 +
===Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor===
 +
{{ABSTRACT_PUBMED_24144283}}
-
The entry 4nud is ON HOLD
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-
Authors: Plotnikov, A.N., Joshua, J., Zhou, M.-M.
+
==Function==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-
Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor
+
==About this Structure==
 +
[[4nud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUD OCA].
 +
 
 +
==Reference==
 +
<ref group="xtra">PMID:024144283</ref><references group="xtra"/><references/>
 +
[[Category: Joshua, J.]]
 +
[[Category: Plotnikov, A N.]]
 +
[[Category: Zhou, M M.]]
 +
[[Category: Transcription]]
 +
[[Category: Transcription factor]]
 +
[[Category: Transcription-transcription inhibitor complex]]

Revision as of 09:15, 2 April 2014

Template:STRUCTURE 4nud

Contents

Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor

Template:ABSTRACT PUBMED 24144283

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4nud is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. doi: 10.1021/jm401334s. Epub 2013 Nov 11. PMID:24144283 doi:http://dx.doi.org/10.1021/jm401334s
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nud"
Personal tools