3wgt

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'''Unreleased structure'''
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{{STRUCTURE_3wgt| PDB=3wgt | SCENE= }}
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===Crystal structure of D-amino acid oxidase mutant===
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{{ABSTRACT_PUBMED_24644036}}
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The entry 3wgt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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Authors: Yasukawa, K., Nakano, S., Asano, Y.
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==About this Structure==
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[[3wgt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGT OCA].
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Description: Crystal structure of D-amino acid oxidase mutant
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==Reference==
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<ref group="xtra">PMID:024644036</ref><references group="xtra"/><references/>
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[[Category: D-amino-acid oxidase]]
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[[Category: Asano, Y.]]
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[[Category: Nakano, S.]]
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[[Category: Yasukawa, K.]]
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[[Category: Fad-binding]]
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[[Category: Oxidase]]
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[[Category: Oxidoreductase]]

Revision as of 09:16, 2 April 2014

Template:STRUCTURE 3wgt

Contents

Crystal structure of D-amino acid oxidase mutant

Template:ABSTRACT PUBMED 24644036

Function

[OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

About this Structure

3wgt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Yasukawa K, Nakano S, Asano Y. Tailoring D-Amino Acid Oxidase from the Pig Kidney to R-Stereoselective Amine Oxidase and its Use in the Deracemization of alpha-Methylbenzylamine. Angew Chem Int Ed Engl. 2014 Mar 18. doi: 10.1002/anie.201308812. PMID:24644036 doi:http://dx.doi.org/10.1002/anie.201308812

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OCA

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