4crt

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'''Unreleased structure'''
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{{STRUCTURE_4crt| PDB=4crt | SCENE= }}
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===Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234===
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{{ABSTRACT_PUBMED_24642166}}
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The entry 4crt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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Authors: Esteban, G., Allan, J., Samadi, A., Mattevi, A., Unzeta, M., Marco-Contelles, J., Binda, C., Ramsay, R.R.
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==About this Structure==
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[[4crt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA].
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Description: Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234
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==Reference==
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<ref group="xtra">PMID:024642166</ref><references group="xtra"/><references/>
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[[Category: Monoamine oxidase]]
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[[Category: Allan, J.]]
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[[Category: Binda, C.]]
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[[Category: Esteban, G.]]
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[[Category: Marco-Contelles, J.]]
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[[Category: Mattevi, A.]]
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[[Category: Ramsay, R R.]]
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[[Category: Samadi, A.]]
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[[Category: Unzeta, M.]]
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[[Category: Alzheimer's disease]]
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[[Category: Drug design]]
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[[Category: Enzyme]]
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[[Category: Flavin]]
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[[Category: Oxidoreductase]]

Revision as of 09:20, 2 April 2014

Template:STRUCTURE 4crt

Contents

Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234

Template:ABSTRACT PUBMED 24642166

Function

[AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

About this Structure

4crt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Esteban G, Allan J, Samadi A, Mattevi A, Unzeta M, Marco-Contelles J, Binda C, Ramsay RR. Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease. Biochim Biophys Acta. 2014 Mar 16. pii: S1570-9639(14)00056-9. doi:, 10.1016/j.bbapap.2014.03.006. PMID:24642166 doi:http://dx.doi.org/10.1016/j.bbapap.2014.03.006

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OCA

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