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4caf

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'''Unreleased structure'''
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{{STRUCTURE_4caf| PDB=4caf | SCENE= }}
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===Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)===
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{{ABSTRACT_PUBMED_24641010}}
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The entry 4caf is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
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Authors: Rackham, M.D., Brannigan, J.A., Rangachari, K., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
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==About this Structure==
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[[4caf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAF OCA].
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Description: Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)
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==Reference==
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<ref group="xtra">PMID:024641010</ref><references group="xtra"/><references/>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Brannigan, J A.]]
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[[Category: Holder, A A.]]
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[[Category: Leatherbarrow, R J.]]
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[[Category: Rackham, M D.]]
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[[Category: Rangachari, K.]]
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[[Category: Tate, E W.]]
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[[Category: Wilkinson, A J.]]
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[[Category: Benzothiophene]]
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[[Category: Inhibitor]]
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[[Category: Malaria]]
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[[Category: Myristoylation]]
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[[Category: Transferase]]

Revision as of 09:24, 2 April 2014

Template:STRUCTURE 4caf

Contents

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)

Template:ABSTRACT PUBMED 24641010

Function

[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]

About this Structure

4caf is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP). J Med Chem. 2014 Mar 27;57(6):2773-88. doi: 10.1021/jm500066b. Epub 2014 Mar 18. PMID:24641010 doi:http://dx.doi.org/10.1021/jm500066b

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OCA

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