4cmz

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m (Protected "4cmz" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4cmz| PDB=4cmz | SCENE= }}
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===An intertwined homodimer of the PDZ homology domain of periaxin===
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The entry 4cmz is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN]] Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 4F. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Han, H., Kursula, P.
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==Function==
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[[http://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN]] Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
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Description: An intertwined homodimer of the PDZ homology domain of periaxin
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==About this Structure==
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[[4cmz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMZ OCA].
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[[Category: Han, H.]]
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[[Category: Kursula, P.]]
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[[Category: Cell cycle]]
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[[Category: Domain swapping]]
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[[Category: Intertwining]]

Revision as of 09:29, 2 April 2014

Template:STRUCTURE 4cmz

Contents

An intertwined homodimer of the PDZ homology domain of periaxin

Disease

[PRAX_HUMAN] Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 4F. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[PRAX_HUMAN] Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.

About this Structure

4cmz is a 3 chain structure. Full crystallographic information is available from OCA.

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OCA

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