4nzm

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'''Unreleased structure'''
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{{STRUCTURE_4nzm| PDB=4nzm | SCENE= }}
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===Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PA-InsP5===
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The entry 4nzm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN]] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>
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Authors: Wang, H., Shears, S.B.
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==About this Structure==
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[[4nzm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZM OCA].
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Description: Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and an Inhibitor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Shears, S B.]]
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[[Category: Wang, H.]]
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[[Category: Atp-grasp fold]]
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[[Category: Drug discovery]]
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[[Category: Enzymology]]
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[[Category: Inositol pyrophosphate kinase]]
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[[Category: Inositol pyrophosphate]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 09:38, 2 April 2014

Template:STRUCTURE 4nzm

Contents

Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PA-InsP5

Function

[VIP2_HUMAN] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.[1] [2]

About this Structure

4nzm is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Fridy PC, Otto JC, Dollins DE, York JD. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. J Biol Chem. 2007 Oct 19;282(42):30754-62. Epub 2007 Aug 9. PMID:17690096 doi:http://dx.doi.org/M704656200
  2. ↑ Choi JH, Williams J, Cho J, Falck JR, Shears SB. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem. 2007 Oct 19;282(42):30763-75. Epub 2007 Aug 16. PMID:17702752 doi:http://dx.doi.org/M704655200

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