Phosphotriesterase
From Proteopedia
| Line 11: | Line 11: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | |||
| + | [[1pta]] – BdPTE – ''Brevundimonas diminuta''<br /> | ||
'''Phosphotriesterase complex with metal ion''' | '''Phosphotriesterase complex with metal ion''' | ||
| - | [[1pta]] – BdPTE – ''Brevundimonas diminuta''<br /> | ||
[[1hzy]] - BdPTE + Zn<br /> | [[1hzy]] - BdPTE + Zn<br /> | ||
[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br /> | [[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br /> | ||
| Line 29: | Line 30: | ||
[[3gtf]], [[3gth]], [[3gti]], [[3gtx]], [[3gu1]], [[3gu2]], [[3gu9]] - DrPTE (mutant) + Co<br /> | [[3gtf]], [[3gth]], [[3gti]], [[3gtx]], [[3gu1]], [[3gu2]], [[3gu9]] - DrPTE (mutant) + Co<br /> | ||
[[3htw]] - DrPTE + Mg + Co<br /> | [[3htw]] - DrPTE + Mg + Co<br /> | ||
| - | [[3orw]] - GkPTE + Co – ''Geobacillus kaustophilus''<br /> | + | [[3orw]], [[3tn3]] - GkPTE + Co – ''Geobacillus kaustophilus''<br /> |
| + | [[3tn4]], [[3tn5]], [[3tn6]], [[3tnb]] - GkPTE (mutant) + Co<br /> | ||
| + | [[4h9u]] - GkPTE + Fe + Zn<br /> | ||
| + | [[4h9v]], [[4h9y]], [[4ha0]] - GkPTE (mutant) + Fe + Zn<br /> | ||
| + | [[4h9z]] - GkPTE (mutant) + Fe + Mn<br /> | ||
[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br /> | [[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br /> | ||
| Line 46: | Line 51: | ||
[[3a3w]], [[3ood]] - AtPTE (mutant) + substrate analog + Co<br /> | [[3a3w]], [[3ood]] - AtPTE (mutant) + substrate analog + Co<br /> | ||
[[3ojg]] - GkPTE + lactone + Fe + Zn<br /> | [[3ojg]] - GkPTE + lactone + Fe + Zn<br /> | ||
| - | [[4e3t]] – | + | [[4h9t]] - GkPTE (mutant) + lactone derivative + Fe + Mn<br /> |
| + | [[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br /> | ||
| + | [[4e3t]] – BdPTE arylesterase variant + transition state analog + Zn <br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:16, 8 April 2014
Phosphotriesterase (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin.
3D structures of phosphotriesterase
Updated on 08-April-2014
1pta – BdPTE – Brevundimonas diminuta
Phosphotriesterase complex with metal ion
1hzy - BdPTE + Zn
2ob3, 2o4m, 2o4q, 2oql - BdPTE (mutant) + Zn
3cs2, 3upm, 3ur2, 3ur5, 3ura, 3urb, 3urn - BdPTE (mutant) + Co
1i0b - BdPTE + Mn
1i0d - BdPTE + Cd + Zn
1jgm - BdPTE + Cd
1p6b - FlPTE (mutant) + Zn – Flavobacterium
2d2j, 3a3x, 3a4j, 3oqe - AtPTE (mutant) + Co – Agrobacterium tumefaciens
2gvu - LvPTE (mutant) + Ca – Loligo vulgaris
2gvw - LvPTE + Ca
2zc1 - DrPTE + Co – Deinococcus radiodurans
3fdk - DrPTE + Zn
3gtf, 3gth, 3gti, 3gtx, 3gu1, 3gu2, 3gu9 - DrPTE (mutant) + Co
3htw - DrPTE + Mg + Co
3orw, 3tn3 - GkPTE + Co – Geobacillus kaustophilus
3tn4, 3tn5, 3tn6, 3tnb - GkPTE (mutant) + Co
4h9u - GkPTE + Fe + Zn
4h9v, 4h9y, 4ha0 - GkPTE (mutant) + Fe + Zn
4h9z - GkPTE (mutant) + Fe + Mn
4gy0, 4gy1 – PTE arylesterase variant + Zn – synthetic
Phosphotriesterase ternary complex with metal ion
1psc - BdPTE + substrate analog + Cd
1eyw, 1dpm, 1ez2 - BdPTE + substrate analog + Zn
3cak - BdPTE + product + Co
1qw7, 3e3h - BdPTE (mutant) + substrate analog + Co
1p6c - FlPTE (mutant) + substrate analog + Zn
2gvv - LvPTE + substrate analog + Ca
2d2g, 2r1k, 2r1l, 2r1m, 2r1p, 3c86 - AtPTE (mutant) + product + Co
2d2h - AtPTE (mutant) + inhibitor + Co
2r1n - AtPTE (mutant) + substrate + Co
3so7 - AtPTE + phosphate + Co
3a3w, 3ood - AtPTE (mutant) + substrate analog + Co
3ojg - GkPTE + lactone + Fe + Zn
4h9t - GkPTE (mutant) + lactone derivative + Fe + Mn
4h9x - GkPTE (mutant) + lactone derivative + Fe + Zn
4e3t – BdPTE arylesterase variant + transition state analog + Zn
