3qnl

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[[Image:3qnl.jpg|left|200px]]
 
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{{STRUCTURE_3qnl| PDB=3qnl | SCENE= }}
{{STRUCTURE_3qnl| PDB=3qnl | SCENE= }}
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===Crystal structure of PrTX-I complexed to Rosmarinic Acid===
===Crystal structure of PrTX-I complexed to Rosmarinic Acid===
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{{ABSTRACT_PUBMED_22205953}}
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==Function==
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[[http://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI]] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
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{{ABSTRACT_PUBMED_22205953}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022205953</ref><references group="xtra"/>
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<ref group="xtra">PMID:022205953</ref><references group="xtra"/><references/>
[[Category: Bothrops pirajai]]
[[Category: Bothrops pirajai]]
[[Category: Fontes, M R.M.]]
[[Category: Fontes, M R.M.]]
[[Category: Santos, J I.dos.]]
[[Category: Santos, J I.dos.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 04:31, 9 April 2014

Template:STRUCTURE 3qnl

Contents

Crystal structure of PrTX-I complexed to Rosmarinic Acid

Template:ABSTRACT PUBMED 22205953

Function

[PA2H1_BOTPI] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).[1] [2]

About this Structure

3qnl is a 2 chain structure with sequence from Bothrops pirajai. Full crystallographic information is available from OCA.

Reference

  • Dos Santos JI, Cardoso FF, Soares AM, Dal Pai Silva M, Gallacci M, Fontes MR. Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA inhibition. PLoS One. 2011;6(12):e28521. Epub 2011 Dec 21. PMID:22205953 doi:10.1371/journal.pone.0028521
  1. ↑ Mancuso LC, Correa MM, Vieira CA, Cunha OA, Lachat JJ, de Araujo HS, Ownby CL, Giglio JR. Fractionation of Bothrops pirajai snake venom: isolation and characterization of piratoxin-I, a new myotoxic protein. Toxicon. 1995 May;33(5):615-26. PMID:7660366
  2. ↑ Dos Santos JI, Cardoso FF, Soares AM, Dal Pai Silva M, Gallacci M, Fontes MR. Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA inhibition. PLoS One. 2011;6(12):e28521. Epub 2011 Dec 21. PMID:22205953 doi:10.1371/journal.pone.0028521

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OCA

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