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4lja

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{{STRUCTURE_4lja| PDB=4lja | SCENE= }}
{{STRUCTURE_4lja| PDB=4lja | SCENE= }}
===ClpB NBD2 R621Q from T. thermophilus in complex with AMPPCP and guanidinium chloride===
===ClpB NBD2 R621Q from T. thermophilus in complex with AMPPCP and guanidinium chloride===
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{{ABSTRACT_PUBMED_24531492}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024531492</ref><references group="xtra"/><references/>
[[Category: Barends, T R.M.]]
[[Category: Barends, T R.M.]]
[[Category: Reinstein, J.]]
[[Category: Reinstein, J.]]

Revision as of 04:32, 9 April 2014

Template:STRUCTURE 4lja

Contents

ClpB NBD2 R621Q from T. thermophilus in complex with AMPPCP and guanidinium chloride

Template:ABSTRACT PUBMED 24531492

Function

[CLPB_THET8] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.[1]

About this Structure

4lja is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zeymer C, Barends TR, Werbeck ND, Schlichting I, Reinstein J. Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):582-95. doi:, 10.1107/S1399004713030629. Epub 2014 Jan 31. PMID:24531492 doi:http://dx.doi.org/10.1107/S1399004713030629
  1. ↑ Motohashi K, Watanabe Y, Yohda M, Yoshida M. Heat-inactivated proteins are rescued by the DnaK.J-GrpE set and ClpB chaperones. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7184-9. PMID:10377389

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OCA

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