4c59

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{{STRUCTURE_4c59| PDB=4c59 | SCENE= }}
{{STRUCTURE_4c59| PDB=4c59 | SCENE= }}
===Structure of GAK kinase in complex with nanobody (NbGAK_4)===
===Structure of GAK kinase in complex with nanobody (NbGAK_4)===
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{{ABSTRACT_PUBMED_24438162}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4c59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C59 OCA].
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[[4c59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C59 OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024438162</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Allerston, C K.]]
[[Category: Allerston, C K.]]

Revision as of 05:03, 9 April 2014

Template:STRUCTURE 4c59

Contents

Structure of GAK kinase in complex with nanobody (NbGAK_4)

Template:ABSTRACT PUBMED 24438162

Function

[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]

About this Structure

4c59 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutierrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Muller S. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399. PMID:24438162 doi:http://dx.doi.org/10.1042/BJ20131399
  1. ↑ Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686

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