2mgx

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{{STRUCTURE_2mgx| PDB=2mgx | SCENE= }}
{{STRUCTURE_2mgx| PDB=2mgx | SCENE= }}
===NMR structure of SRA1p C-terminal domain===
===NMR structure of SRA1p C-terminal domain===
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{{ABSTRACT_PUBMED_24486611}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024486611</ref><references group="xtra"/><references/>
[[Category: Bilinovich, S M.]]
[[Category: Bilinovich, S M.]]
[[Category: Buchan, G J.]]
[[Category: Buchan, G J.]]

Revision as of 05:24, 9 April 2014

Template:STRUCTURE 2mgx

Contents

NMR structure of SRA1p C-terminal domain

Template:ABSTRACT PUBMED 24486611

Function

[SRA1_HUMAN] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.[1] [2] [3] [4] [5]

About this Structure

2mgx is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC. The C-Terminal Domain of SRA1p Has a Fold More Similar to PRP18 than to an RRM and Does Not Directly Bind to the SRA1 RNA STR7 Region. J Mol Biol. 2014 Apr 17;426(8):1753-65. doi: 10.1016/j.jmb.2014.01.007. Epub 2014, Jan 29. PMID:24486611 doi:http://dx.doi.org/10.1016/j.jmb.2014.01.007
  1. ↑ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27. PMID:10199399
  2. ↑ Deblois G, Giguere V. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):123-31. PMID:12943696
  3. ↑ Lanz RB, Chua SS, Barron N, Soder BM, DeMayo F, O'Malley BW. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol. 2003 Oct;23(20):7163-76. PMID:14517287
  4. ↑ Coleman KM, Lam V, Jaber BM, Lanz RB, Smith CL. SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. Biochem Biophys Res Commun. 2004 Oct 8;323(1):332-8. PMID:15351741 doi:http://dx.doi.org/10.1016/j.bbrc.2004.08.090
  5. ↑ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. PMID:15147866 doi:http://dx.doi.org/10.1016/j.febslet.2004.03.104

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OCA

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