4om3

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'''Unreleased structure'''
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{{STRUCTURE_4om3| PDB=4om3 | SCENE= }}
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===Crystal structure of human TLE1 Q-domain residues 20-156===
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{{ABSTRACT_PUBMED_24596249}}
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The entry 4om3 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN]] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
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Authors: Chodaparambil, J.V., Weis, W.I.
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==About this Structure==
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[[4om3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM3 OCA].
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Description: Crystal structure of human TLE1 Q-domain residues 20-156
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==Reference==
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<ref group="xtra">PMID:024596249</ref><references group="xtra"/><references/>
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[[Category: Chodaparambil, J V.]]
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[[Category: Weis, W I.]]
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[[Category: Dna binding]]
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[[Category: Helix-turn-helix]]
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[[Category: Tcf/lef]]
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[[Category: Tetramer]]
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[[Category: Transcription]]
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[[Category: Wnt repressor]]

Revision as of 06:23, 9 April 2014

Template:STRUCTURE 4om3

Contents

Crystal structure of human TLE1 Q-domain residues 20-156

Template:ABSTRACT PUBMED 24596249

Function

[TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.[1]

About this Structure

4om3 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014 Apr 1;33(7):719-31. doi: 10.1002/embj.201387188. Epub 2014 Mar 3. PMID:24596249 doi:http://dx.doi.org/10.1002/embj.201387188
  1. ↑ Tetsuka T, Uranishi H, Imai H, Ono T, Sonta S, Takahashi N, Asamitsu K, Okamoto T. Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J Biol Chem. 2000 Feb 11;275(6):4383-90. PMID:10660609

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