4bpi

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'''Unreleased structure'''
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{{STRUCTURE_4bpi| PDB=4bpi | SCENE= }}
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===Mcl-1 bound to alpha beta Puma BH3 peptide 2===
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{{ABSTRACT_PUBMED_23929624}}
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The entry 4bpi is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
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Authors: Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.
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==About this Structure==
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[[4bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA].
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Description: Mcl-1 bound to alpha beta Puma BH3 peptide 2
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==Reference==
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<ref group="xtra">PMID:023929624</ref><references group="xtra"/><references/>
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[[Category: Checco, J W.]]
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[[Category: Fairlie, W D.]]
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[[Category: Gellman, S H.]]
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[[Category: Lee, E F.]]
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[[Category: Smith, B J.]]
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[[Category: Apoptosis]]
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[[Category: Bim]]
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[[Category: Chimera]]

Revision as of 06:25, 9 April 2014

Template:STRUCTURE 4bpi

Contents

Mcl-1 bound to alpha beta Puma BH3 peptide 2

Template:ABSTRACT PUBMED 23929624

Function

[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.

About this Structure

4bpi is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie WD. Structure-guided rational design of alpha/beta-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem. 2013 Sep 2;14(13):1564-72. doi: 10.1002/cbic.201300351. Epub 2013, Aug 8. PMID:23929624 doi:http://dx.doi.org/10.1002/cbic.201300351

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OCA

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