4lvh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4lvh| PDB=4lvh | SCENE= }}
 +
===Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin===
 +
{{ABSTRACT_PUBMED_24587046}}
-
The entry 4lvh is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-
Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H.
+
==About this Structure==
 +
[[4lvh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA].
-
Description: Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin
+
==Reference==
 +
<ref group="xtra">PMID:024587046</ref><references group="xtra"/><references/>
 +
[[Category: Mus musculus]]
 +
[[Category: Cho, K J.]]
 +
[[Category: Kim, K H.]]
 +
[[Category: Kim, S.]]
 +
[[Category: Lee, J H.]]
 +
[[Category: Seok, J H.]]
 +
[[Category: Antibody]]
 +
[[Category: Hemagglutinin]]
 +
[[Category: Immune system]]
 +
[[Category: Influenza virus]]

Revision as of 06:26, 9 April 2014

Template:STRUCTURE 4lvh

Contents

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin

Template:ABSTRACT PUBMED 24587046

Function

[C5MQE6_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

About this Structure

4lvh is a 12 chain structure with sequence from [1] and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Cho KJ, Hong KW, Kim SH, Seok JH, Kim S, Lee JH, Saelens X, Kim KH. Insight into highly conserved h1 subtype-specific epitopes in influenza virus hemagglutinin. PLoS One. 2014 Feb 26;9(2):e89803. doi: 10.1371/journal.pone.0089803. eCollection, 2014. PMID:24587046 doi:http://dx.doi.org/10.1371/journal.pone.0089803

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lvh"
Personal tools