4k26

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-	'''Unreleased structure'''	+	{{STRUCTURE_4k26| PDB=4k26 | SCENE= }}
		+	===4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes===
		+	{{ABSTRACT_PUBMED_23845218}}
-	The entry 4k26 is ON HOLD until Apr 08 2015	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
-	Authors: Loenze, P., Schimanski-Breves, S., Vonderheyden, C., Engel, C.K.	+	==About this Structure==
		+	[[4k26]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K26 OCA].
-	Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes	+	==Reference==
		+	<ref group="xtra">PMID:023845218</ref><references group="xtra"/><references/>
		+	[[Category: 11-beta-hydroxysteroid dehydrogenase]]
		+	[[Category: Engel, C K.]]
		+	[[Category: Loenze, P.]]
		+	[[Category: Schimanski-Breves, S.]]
		+	[[Category: Vonderheyden, C.]]
		+	[[Category: Alpha and beta protein]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Short chain dehydrogenase]]

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Revision as of 06:27, 9 April 2014

Template:STRUCTURE 4k26

Contents 1 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes 2 Function 3 About this Structure 4 Reference

4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes

Template:ABSTRACT PUBMED 23845218

Function

[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

About this Structure

4k26 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Bohme T, Engel CK, Farjot G, Gussregen S, Haack T, Tschank G, Ritter K. 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ss-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4685-91. doi:, 10.1016/j.bmcl.2013.05.102. Epub 2013 Jun 11. PMID:23845218 doi:http://dx.doi.org/10.1016/j.bmcl.2013.05.102