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4k26

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'''Unreleased structure'''
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{{STRUCTURE_4k26| PDB=4k26 | SCENE= }}
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===4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes===
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{{ABSTRACT_PUBMED_23845218}}
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The entry 4k26 is ON HOLD until Apr 08 2015
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==Function==
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[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
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Authors: Loenze, P., Schimanski-Breves, S., Vonderheyden, C., Engel, C.K.
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==About this Structure==
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[[4k26]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K26 OCA].
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Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes
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==Reference==
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<ref group="xtra">PMID:023845218</ref><references group="xtra"/><references/>
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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[[Category: Engel, C K.]]
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[[Category: Loenze, P.]]
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[[Category: Schimanski-Breves, S.]]
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[[Category: Vonderheyden, C.]]
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[[Category: Alpha and beta protein]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Short chain dehydrogenase]]

Revision as of 06:27, 9 April 2014

Template:STRUCTURE 4k26

Contents

4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes

Template:ABSTRACT PUBMED 23845218

Function

[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

About this Structure

4k26 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Bohme T, Engel CK, Farjot G, Gussregen S, Haack T, Tschank G, Ritter K. 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ss-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4685-91. doi:, 10.1016/j.bmcl.2013.05.102. Epub 2013 Jun 11. PMID:23845218 doi:http://dx.doi.org/10.1016/j.bmcl.2013.05.102

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OCA

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