4hne

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'''Unreleased structure'''
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{{STRUCTURE_4hne| PDB=4hne | SCENE= }}
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===Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP===
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{{ABSTRACT_PUBMED_24675427}}
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The entry 4hne is ON HOLD until Apr 18 2015
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==Function==
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[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
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Authors: Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
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==About this Structure==
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[[4hne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNE OCA].
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Description: Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP
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==Reference==
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<ref group="xtra">PMID:024675427</ref><references group="xtra"/><references/>
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[[Category: 1-phosphatidylinositol 4-kinase]]
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[[Category: Chen, C.]]
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[[Category: Sun, F.]]
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[[Category: Zhai, Y.]]
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[[Category: Zhang, K.]]
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[[Category: Zhou, Q.]]
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[[Category: Atp binding]]
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[[Category: Lipid kinase]]
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[[Category: Membrane anchoring]]
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[[Category: Palmitoylation]]
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[[Category: Pi3k/pi4k kinase]]
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[[Category: Transferase]]

Revision as of 06:30, 9 April 2014

Template:STRUCTURE 4hne

Contents

Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP

Template:ABSTRACT PUBMED 24675427

Function

[P4K2A_HUMAN] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.

About this Structure

4hne is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zhou Q, Li J, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K, Sun F, Chen C. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIalpha. Nat Commun. 2014 Mar 28;5:3552. doi: 10.1038/ncomms4552. PMID:24675427 doi:http://dx.doi.org/10.1038/ncomms4552

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