3j6l

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'''Unreleased structure'''
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{{STRUCTURE_3j6l| PDB=3j6l | SCENE= }}
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===Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle===
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{{ABSTRACT_PUBMED_24623425}}
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The entry 3j6l is ON HOLD until sometime in the future
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==Function==
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[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
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Authors: Organtini, L.J., Makhov, A.M., Conway, J.F., Hafenstein, S., Carson, S.D.
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==About this Structure==
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[[3j6l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6L OCA].
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Description: Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle
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==Reference==
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<ref group="xtra">PMID:024623425</ref><references group="xtra"/><references/>
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[[Category: Carson, S D.]]
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[[Category: Conway, J F.]]
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[[Category: Hafenstein, S.]]
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[[Category: Makhov, A M.]]
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[[Category: Organtini, L J.]]
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[[Category: Car]]
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[[Category: Cell adhesion]]
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[[Category: Coxsackievirus b3]]
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[[Category: Cvb3]]

Revision as of 06:31, 9 April 2014

Template:STRUCTURE 3j6l

Contents

Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle

Template:ABSTRACT PUBMED 24623425

Function

[CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.[1] [2] [3] [4]

About this Structure

3j6l is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD. Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle. J Virol. 2014 Mar 12. PMID:24623425 doi:http://dx.doi.org/10.1128/JVI.00299-14
  1. ↑ Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6. PMID:9096397
  2. ↑ Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15191-6. Epub 2001 Dec 4. PMID:11734628 doi:10.1073/pnas.261452898
  3. ↑ Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J, Welsh MJ. Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell. 2002 Sep 20;110(6):789-99. PMID:12297051
  4. ↑ Zen K, Liu Y, McCall IC, Wu T, Lee W, Babbin BA, Nusrat A, Parkos CA. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell. 2005 Jun;16(6):2694-703. Epub 2005 Mar 30. PMID:15800062 doi:E05-01-0036

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