Plasminogen

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	== 3D Structures of plasminogen ==		== 3D Structures of plasminogen ==
-	''Updated June 2012''	+	Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	[[4dur]], [[4duu]] – hPLG 2	+	[[4dur]], [[4duu]], [[4a5t]] – hPLG 2
	===Plasminogen kringle 1===		===Plasminogen kringle 1===
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	[[1bml]] – hPLN catalytic domain + streptokinase<BR />		[[1bml]] – hPLN catalytic domain + streptokinase<BR />
	[[1bui]] – hPLN light chain + staphylokinase		[[1bui]] – hPLN light chain + staphylokinase
		+
		+	===Microplasmin===
		+
		+	[[3uir]] – hPLN + textilinin-1<br />
	[[Category:Topic Page]]		[[Category:Topic Page]]

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Revision as of 06:38, 9 April 2014

Template:STRUCTURE 1qrz

Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.

3D Structures of plasminogen

Updated on 09-April-2014

4dur, 4duu, 4a5t – hPLG 2

Plasminogen kringle 1

1pkr - hPLG kringle 1 – human
1cea - hPLG kringle 1 + e-aminocaprioic acid
1hpj, 1hpk - hPLG kringle 1 + 6-aminohexanoic acid - NMR
1ceb - hPLG kringle 1 + AMCHA

Plasminogen kringle 2

1b2i - hPLG kringle 2 (mutant) – NMR
1i5k - hPLG kringle 2 (mutant) + M2 protein peptide
2kj4 – hPLG kringle 2 + M2 protein peptide – NMR

Plasminogen kringle 3

2l0s - hPLG kringle 3 – NMR

Plasminogen kringle 4

1pk4, 1pmk, 1pml, 1krn – hPLG kringle 4
2pk4 - hPLG kringle 4 + e-aminocaprioic acid

Plasminogen kringle 5

5hpg - hPLG kringle 5
2knf - hPLG kringle 5 – NMR

Plasminogen catalytic domain

1qrz, 1ddj, 1rjx – hPLG catalytic domain (mutant)
1l4d, 1l4z - hPLG catalytic domain (mutant) + streptokinase α domain

Plasmin

1bml – hPLN catalytic domain + streptokinase
1bui – hPLN light chain + staphylokinase

Microplasmin

3uir – hPLN + textilinin-1