4kgc

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{{STRUCTURE_4kgc| PDB=4kgc | SCENE= }}
{{STRUCTURE_4kgc| PDB=4kgc | SCENE= }}
===Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM===
===Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM===
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{{ABSTRACT_PUBMED_24637564}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4kgc]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGC OCA].
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[[4kgc]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGC OCA].
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==Reference==
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<ref group="xtra">PMID:024637564</ref><references group="xtra"/><references/>
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[[Category: African clawed frog]]
[[Category: Adhireksan, Z.]]
[[Category: Adhireksan, Z.]]
[[Category: Davey, C A.]]
[[Category: Davey, C A.]]

Revision as of 07:27, 16 April 2014

Template:STRUCTURE 4kgc

Contents

Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM

Template:ABSTRACT PUBMED 24637564

Function

[H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

About this Structure

4kgc is a 10 chain structure with sequence from African clawed frog. Full crystallographic information is available from OCA.

Reference

  • Adhireksan Z, Davey GE, Campomanes P, Groessl M, Clavel CM, Yu H, Nazarov AA, Yeo CH, Ang WH, Droge P, Rothlisberger U, Dyson PJ, Davey CA. Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity. Nat Commun. 2014 Mar 18;5:3462. doi: 10.1038/ncomms4462. PMID:24637564 doi:http://dx.doi.org/10.1038/ncomms4462

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