3f02
From Proteopedia
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{{STRUCTURE_3f02| PDB=3f02 | SCENE= }} | {{STRUCTURE_3f02| PDB=3f02 | SCENE= }} | ||
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===Cleaved human neuroserpin=== | ===Cleaved human neuroserpin=== | ||
| + | {{ABSTRACT_PUBMED_19265707}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/NEUS_HUMAN NEUS_HUMAN]] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3f02]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3f02]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F02 OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019265707</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019265707</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Bolognesi, M.]] | [[Category: Bolognesi, M.]] | ||
[[Category: Caccia, S.]] | [[Category: Caccia, S.]] | ||
Revision as of 07:35, 16 April 2014
Contents |
Cleaved human neuroserpin
Template:ABSTRACT PUBMED 19265707
Disease
[NEUS_HUMAN] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.
Function
[NEUS_HUMAN] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
About this Structure
3f02 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M. Human neuroserpin: structure and time-dependent inhibition. J Mol Biol. 2009 Apr 24;388(1):109-21. Epub 2009 Mar 2. PMID:19265707 doi:10.1016/j.jmb.2009.02.056
