3sw8
From Proteopedia
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{{STRUCTURE_3sw8| PDB=3sw8 | SCENE= }} | {{STRUCTURE_3sw8| PDB=3sw8 | SCENE= }} | ||
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===Strep Peptide Deformylase with a time dependent dichlorobenzamide-reverse hydroxamic acid=== | ===Strep Peptide Deformylase with a time dependent dichlorobenzamide-reverse hydroxamic acid=== | ||
| + | {{ABSTRACT_PUBMED_21711014}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q939R9_STREE Q939R9_STREE]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).[HAMAP-Rule:MF_00163] | |
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==About this Structure== | ==About this Structure== | ||
| - | [[3sw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3sw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SW8 OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021711014</ref>< | + | <ref group="xtra">PMID:021711014</ref><references group="xtra"/><references/> |
[[Category: Peptide deformylase]] | [[Category: Peptide deformylase]] | ||
| - | [[Category: Streptococcus pneumoniae]] | ||
[[Category: Campobasso, N.]] | [[Category: Campobasso, N.]] | ||
[[Category: Smith, K J.]] | [[Category: Smith, K J.]] | ||
Revision as of 07:39, 16 April 2014
Contents |
Strep Peptide Deformylase with a time dependent dichlorobenzamide-reverse hydroxamic acid
Template:ABSTRACT PUBMED 21711014
Function
[Q939R9_STREE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).[HAMAP-Rule:MF_00163]
About this Structure
3sw8 is a 1 chain structure with sequence from "diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886. Full crystallographic information is available from OCA.
Reference
- Totoritis R, Duraiswami C, Taylor AN, Kerrigan JJ, Campobasso N, Ward P, King BW, Murray-Thompson MF, Jones AD, Van Aller G, Aubart KM, Zalacain M, Thrall SH, Meek TD, Schwartz B. Understanding the Origins of Time Dependent Inhibition by Polypeptide Deformylase Inhibitors. Biochemistry. 2011 Jun 28. PMID:21711014 doi:10.1021/bi200655g
