4cq1

From Proteopedia

Revision as of 07:49, 16 April 2014

Template:STRUCTURE 4cq1

Crystal structure of the neuronal isoform of PTB

Template:ABSTRACT PUBMED 24688880

Function

[PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.^{[1] [2]}

About this Structure

4cq1 is a 8 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 4cko. Full crystallographic information is available from OCA.

Reference

• Joshi A, Esteve V, Buckroyd AN, Blatter M, Allain FH, Curry S. Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB). PeerJ. 2014 Mar 13;2:e305. doi: 10.7717/peerj.305. eCollection 2014. PMID:24688880 doi:http://dx.doi.org/10.7717/peerj.305

1. ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(20):7463-79. PMID:11003644
2. ↑ Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003 Mar;11(3):757-71. PMID:12667457