4jij
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4jij]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIJ OCA]. | + | [[4jij]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIJ OCA]. |
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| + | ==See Also== | ||
| + | *[[Matrix metalloproteinase|Matrix metalloproteinase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024583051</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024583051</ref><references group="xtra"/><references/> | ||
[[Category: Gelatinase B]] | [[Category: Gelatinase B]] | ||
| + | [[Category: Human]] | ||
[[Category: Amoura, M.]] | [[Category: Amoura, M.]] | ||
[[Category: Cassar-Lajeunesse, E.]] | [[Category: Cassar-Lajeunesse, E.]] | ||
Revision as of 08:08, 16 April 2014
Contents |
Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate
Template:ABSTRACT PUBMED 24583051
Disease
[MMP9_HUMAN] Defects in MMP9 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.[1] Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.
Function
[MMP9_HUMAN] May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.[2]
About this Structure
4jij is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Tranchant I, Vera L, Czarny B, Amoura M, Cassar E, Beau F, Stura EA, Dive V. Halogen Bonding Controls Selectivity of FRET Substrate Probes for MMP-9. Chem Biol. 2014 Feb 25. pii: S1074-5521(14)00031-3. doi:, 10.1016/j.chembiol.2014.01.008. PMID:24583051 doi:http://dx.doi.org/10.1016/j.chembiol.2014.01.008
- ↑ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet. 2008 May;82(5):1122-9. Epub 2008 May 1. PMID:18455130 doi:S0002-9297(08)00223-1
- ↑ Tschesche H, Knauper V, Kramer S, Michaelis J, Oberhoff R, Reinke H. Latent collagenase and gelatinase from human neutrophils and their activation. Matrix Suppl. 1992;1:245-55. PMID:1480034
