4hg9

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[[Image:4hg9.jpg|left|200px]]
 
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{{STRUCTURE_4hg9| PDB=4hg9 | SCENE= }}
{{STRUCTURE_4hg9| PDB=4hg9 | SCENE= }}
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===Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom===
===Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom===
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==Function==
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[[http://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA]] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
==About this Structure==
==About this Structure==
[[4hg9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HG9 OCA].
[[4hg9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HG9 OCA].
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==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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==Reference==
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<references group="xtra"/><references/>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
[[Category: Li, X.]]
[[Category: Li, X.]]

Revision as of 08:11, 16 April 2014

Template:STRUCTURE 4hg9

Contents

Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom

Function

[PA2BB_GLOHA] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.[1] [2]

About this Structure

4hg9 is a 4 chain structure with sequence from Gloydius halys. Full crystallographic information is available from OCA.

See Also

Reference

  1. ↑ Faure G, Gowda VT, Maroun RC. Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics. BMC Struct Biol. 2007 Dec 6;7:82. PMID:18062812 doi:http://dx.doi.org/10.1186/1472-6807-7-82
  2. ↑ Zhao K, Zhou Y, Lin Z. Structure of basic phospholipase A2 from Agkistrodon halys Pallas: implications for its association, hemolytic and anticoagulant activities. Toxicon. 2000 Jul;38(7):901-16. PMID:10728829

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