3p53
From Proteopedia
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{{STRUCTURE_3p53| PDB=3p53 | SCENE= }} | {{STRUCTURE_3p53| PDB=3p53 | SCENE= }} | ||
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===Structure of fascin=== | ===Structure of fascin=== | ||
| + | {{ABSTRACT_PUBMED_21685497}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN]] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[3p53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3p53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P53 OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021685497</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021685497</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Dominguez, R.]] | [[Category: Dominguez, R.]] | ||
[[Category: Jansen, S.]] | [[Category: Jansen, S.]] | ||
[[Category: Beta-trefoil domain]] | [[Category: Beta-trefoil domain]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 08:31, 16 April 2014
Contents |
Structure of fascin
Template:ABSTRACT PUBMED 21685497
Function
[FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.[1] [2] [3] [4]
About this Structure
3p53 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Jansen S, Collins A, Yang C, Rebowski G, Svitkina T, Dominguez R. Mechanism of actin filament bundling by fascin. J Biol Chem. 2011 Aug 26;286(34):30087-96. Epub 2011 Jun 18. PMID:21685497 doi:10.1074/jbc.M111.251439
- ↑ Adams JC. Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes. Mol Biol Cell. 1997 Nov;8(11):2345-63. PMID:9362073
- ↑ Yamashiro S, Yamakita Y, Ono S, Matsumura F. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998 May;9(5):993-1006. PMID:9571235
- ↑ Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, Konig I, Anderson K, Machesky LM. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 2010 Feb 23;20(4):339-45. doi: 10.1016/j.cub.2009.12.035. Epub 2010, Feb 4. PMID:20137952 doi:10.1016/j.cub.2009.12.035
- ↑ Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Apr 15;464(7291):1062-6. PMID:20393565 doi:10.1038/nature08978
