2ymy

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m (Protected "2ymy" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2ymy| PDB=2ymy | SCENE= }}
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===Structure of the murine Nore1-Sarah domain===
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{{ABSTRACT_PUBMED_23331050}}
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The entry 2ymy is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE]] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref>
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Authors: Makbul, C., Schwarz, D., Aruxandei, D.C., Wolf, E., Hofmann, E., Herrmann, C.
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==About this Structure==
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[[2ymy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMY OCA].
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Description: Structure of the murine Nore1-Sarah domain
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==Reference==
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<ref group="xtra">PMID:023331050</ref><references group="xtra"/><references/>
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[[Category: Lk3 transgenic mice]]
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[[Category: Aruxandei, D C.]]
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[[Category: Herrmann, C.]]
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[[Category: Hofmann, E.]]
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[[Category: Makbul, C.]]
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[[Category: Schwarz, D.]]
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[[Category: Wolf, E.]]
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[[Category: Apoptosis]]
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[[Category: Coiled-coil]]
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[[Category: Ras association domain family]]
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[[Category: Tumor suppressor]]

Revision as of 08:36, 16 April 2014

Template:STRUCTURE 2ymy

Contents

Structure of the murine Nore1-Sarah domain

Template:ABSTRACT PUBMED 23331050

Function

[RASF5_MOUSE] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.[1]

About this Structure

2ymy is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  • Makbul C, Constantinescu Aruxandei D, Hofmann E, Schwarz D, Wolf E, Herrmann C. Structural and Thermodynamic Characterization of Nore1-SARAH: A Small, Helical Module Important in Signal Transduction Networks. Biochemistry. 2013 Feb 12;52(6):1045-54. doi: 10.1021/bi3014642. Epub 2013 Jan, 30. PMID:23331050 doi:http://dx.doi.org/10.1021/bi3014642
  1. ↑ Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002 Feb 19;12(4):253-65. PMID:11864565

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