4np2

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'''Unreleased structure'''
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{{STRUCTURE_4np2| PDB=4np2 | SCENE= }}
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===Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule===
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{{ABSTRACT_PUBMED_24606063}}
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The entry 4np2 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
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Authors: Liu, L.K., Finzel, B.
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==About this Structure==
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[[4np2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NP2 OCA].
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Description: Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule
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==Reference==
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<ref group="xtra">PMID:024606063</ref><references group="xtra"/><references/>
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[[Category: Finzel, B.]]
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[[Category: Liu, L K.]]
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[[Category: Cell adhesion-inhibitor complex]]
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[[Category: Cell surface]]
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[[Category: Cell surface receptor]]
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[[Category: Hyaluronan]]
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[[Category: Link module]]
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[[Category: Non-glycosylated]]

Revision as of 09:39, 16 April 2014

Template:STRUCTURE 4np2

Contents

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

Template:ABSTRACT PUBMED 24606063

Function

[CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.

About this Structure

4np2 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Liu LK, Finzel BC. Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J Med Chem. 2014 Mar 27;57(6):2714-25. doi: 10.1021/jm5000276. Epub 2014 Mar 7. PMID:24606063 doi:http://dx.doi.org/10.1021/jm5000276

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OCA

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