4oww

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'''Unreleased structure'''
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{{STRUCTURE_4oww| PDB=4oww | SCENE= }}
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===Structural basis of SOSS1 in complex with a 35nt ssDNA===
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{{ABSTRACT_PUBMED_24630995}}
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The entry 4oww is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SOSSC_HUMAN SOSSC_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> [[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref> [[http://www.uniprot.org/uniprot/INT3_HUMAN INT3_HUMAN]] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
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Authors: Ren, W., Sun, Q., Tang, X., Song, H.
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==About this Structure==
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[[4oww]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWW OCA].
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Description: Structural basis of SOSS1 in complex with a 35nt ssDNA
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==Reference==
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<ref group="xtra">PMID:024630995</ref><references group="xtra"/><references/>
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[[Category: Ren, W.]]
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[[Category: Song, H.]]
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[[Category: Sun, Q.]]
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[[Category: Tang, X.]]
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[[Category: Dna double-strand break]]
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[[Category: Homologous recombination]]
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[[Category: Soss1 complex]]
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[[Category: Ssdna-binding protein]]

Revision as of 09:45, 16 April 2014

Template:STRUCTURE 4oww

Contents

Structural basis of SOSS1 in complex with a 35nt ssDNA

Template:ABSTRACT PUBMED 24630995

Function

[SOSSC_HUMAN] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.[1] [2] [SOSB1_HUMAN] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.[3] [4] [5] [INT3_HUMAN] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.[6] [7] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.[8] [9]

About this Structure

4oww is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ren W, Chen H, Sun Q, Tang X, Lim SC, Huang J, Song H. Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep. 2014 Mar 27;6(6):982-91. doi: 10.1016/j.celrep.2014.02.020. Epub 2014, Mar 13. PMID:24630995 doi:http://dx.doi.org/10.1016/j.celrep.2014.02.020
  1. ↑ Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem. 2009 Aug 28;284(35):23525-31. doi: 10.1074/jbc.C109.039586. Epub, 2009 Jul 14. PMID:19605351 doi:http://dx.doi.org/10.1074/jbc.C109.039586
  2. ↑ Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14;35(3):384-93. doi: 10.1016/j.molcel.2009.06.011. PMID:19683501 doi:http://dx.doi.org/10.1016/j.molcel.2009.06.011
  3. ↑ Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 2008 May 29;453(7195):677-81. doi: 10.1038/nature06883. Epub 2008 Apr 30. PMID:18449195 doi:http://dx.doi.org/10.1038/nature06883
  4. ↑ Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem. 2009 Aug 28;284(35):23525-31. doi: 10.1074/jbc.C109.039586. Epub, 2009 Jul 14. PMID:19605351 doi:http://dx.doi.org/10.1074/jbc.C109.039586
  5. ↑ Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14;35(3):384-93. doi: 10.1016/j.molcel.2009.06.011. PMID:19683501 doi:http://dx.doi.org/10.1016/j.molcel.2009.06.011
  6. ↑ Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem. 2009 Aug 28;284(35):23525-31. doi: 10.1074/jbc.C109.039586. Epub, 2009 Jul 14. PMID:19605351 doi:http://dx.doi.org/10.1074/jbc.C109.039586
  7. ↑ Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14;35(3):384-93. doi: 10.1016/j.molcel.2009.06.011. PMID:19683501 doi:http://dx.doi.org/10.1016/j.molcel.2009.06.011
  8. ↑ Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem. 2009 Aug 28;284(35):23525-31. doi: 10.1074/jbc.C109.039586. Epub, 2009 Jul 14. PMID:19605351 doi:http://dx.doi.org/10.1074/jbc.C109.039586
  9. ↑ Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14;35(3):384-93. doi: 10.1016/j.molcel.2009.06.011. PMID:19683501 doi:http://dx.doi.org/10.1016/j.molcel.2009.06.011

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