4n0h

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m (Protected "4n0h" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4n0h| PDB=4n0h | SCENE= }}
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===Crystal structure of S. cerevisiae mitochondrial GatFAB===
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{{ABSTRACT_PUBMED_24692665}}
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The entry 4n0h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GATA_YEAST GATA_YEAST]] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling.<ref>PMID:19417106</ref> <ref>PMID:18667535</ref> [[http://www.uniprot.org/uniprot/GATF_YEAST GATF_YEAST]] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.<ref>PMID:19417106</ref> <ref>PMID:21799017</ref> [[http://www.uniprot.org/uniprot/GATB_YEAST GATB_YEAST]] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).<ref>PMID:19417106</ref>
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Authors: Araiso, Y., Ishitani, R., Nureki, O.
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==About this Structure==
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[[4n0h]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0H OCA].
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Description: Crystal structure of protein
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==Reference==
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<ref group="xtra">PMID:024692665</ref><references group="xtra"/><references/>
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[[Category: Araiso, Y.]]
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[[Category: Ishitani, R.]]
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[[Category: Nureki, O.]]
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[[Category: Amidotransferase]]
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[[Category: Ligase]]

Revision as of 09:47, 16 April 2014

Template:STRUCTURE 4n0h

Contents

Crystal structure of S. cerevisiae mitochondrial GatFAB

Template:ABSTRACT PUBMED 24692665

Function

[GATA_YEAST] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling.[1] [2] [GATF_YEAST] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.[3] [4] [GATB_YEAST] Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).[5]

About this Structure

4n0h is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Araiso Y, Huot JL, Sekiguchi T, Frechin M, Fischer F, Enkler L, Senger B, Ishitani R, Becker HD, Nureki O. Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases. Nucleic Acids Res. 2014 Apr 1. PMID:24692665 doi:http://dx.doi.org/10.1093/nar/gku234
  1. ↑ Frechin M, Senger B, Braye M, Kern D, Martin RP, Becker HD. Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev. 2009 May 1;23(9):1119-30. doi: 10.1101/gad.518109. PMID:19417106 doi:http://dx.doi.org/10.1101/gad.518109
  2. ↑ Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Oct;19(10):4506-20. Epub 2008 Jul 30. PMID:18667535 doi:http://dx.doi.org/E07-11-1188
  3. ↑ Frechin M, Senger B, Braye M, Kern D, Martin RP, Becker HD. Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev. 2009 May 1;23(9):1119-30. doi: 10.1101/gad.518109. PMID:19417106 doi:http://dx.doi.org/10.1101/gad.518109
  4. ↑ Barros MH, Rak M, Paulela JA, Tzagoloff A. Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase. J Biol Chem. 2011 Sep 23;286(38):32937-47. doi: 10.1074/jbc.M111.265371. Epub, 2011 Jul 28. PMID:21799017 doi:http://dx.doi.org/10.1074/jbc.M111.265371
  5. ↑ Frechin M, Senger B, Braye M, Kern D, Martin RP, Becker HD. Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev. 2009 May 1;23(9):1119-30. doi: 10.1101/gad.518109. PMID:19417106 doi:http://dx.doi.org/10.1101/gad.518109

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