4o7d

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'''Unreleased structure'''
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{{STRUCTURE_4o7d| PDB=4o7d | SCENE= }}
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===Crystal structure of human glutaminase in complex DON===
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{{ABSTRACT_PUBMED_24451979}}
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The entry 4o7d is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
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Authors: Thangavelu, K., Sivaraman, J.
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==About this Structure==
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[[4o7d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7D OCA].
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Description: Crystal structure of human glutaminase in complex DON
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==Reference==
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<ref group="xtra">PMID:024451979</ref><references group="xtra"/><references/>
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[[Category: Glutaminase]]
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[[Category: Sivaraman, J.]]
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[[Category: Thangavelu, K.]]
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[[Category: Hydrolase]]

Revision as of 09:48, 16 April 2014

Template:STRUCTURE 4o7d

Contents

Crystal structure of human glutaminase in complex DON

Template:ABSTRACT PUBMED 24451979

Function

[GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

About this Structure

4o7d is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Thangavelu K, Chong QY, Low BC, Sivaraman J. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827. PMID:24451979 doi:http://dx.doi.org/10.1038/srep03827

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OCA

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