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4cml

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'''Unreleased structure'''
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{{STRUCTURE_4cml| PDB=4cml | SCENE= }}
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===Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4- bisphosphate===
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{{ABSTRACT_PUBMED_24704254}}
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The entry 4cml is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>
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Authors: Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Moche, M., Nyman, T., Schuler, H., Silvander, C., Thorsell, A.G., Weigelt, J., Welin, M., Nordlund, P.
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==About this Structure==
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[[4cml]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CML OCA].
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Description: Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4-bisphosphate
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==Reference==
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<ref group="xtra">PMID:024704254</ref><references group="xtra"/><references/>
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[[Category: Phosphoinositide 5-phosphatase]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Berglund, H.]]
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[[Category: Bountra, C.]]
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[[Category: Edwards, A M.]]
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[[Category: Ekblad, T.]]
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[[Category: Flodin, S.]]
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[[Category: Graslund, S.]]
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[[Category: Karlberg, T.]]
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[[Category: Moche, M.]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman, T.]]
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[[Category: Schuler, H.]]
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[[Category: Silvander, C.]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues, L.]]
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[[Category: Weigelt, J.]]
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[[Category: Welin, M.]]
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[[Category: Hydrolase]]
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[[Category: Magnesium binding]]
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[[Category: Sgc]]
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[[Category: Signalling]]
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[[Category: Structural genomics consortium stockholm]]

Revision as of 09:51, 16 April 2014

Template:STRUCTURE 4cml

Contents

Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4- bisphosphate

Template:ABSTRACT PUBMED 24704254

Function

[I5P2_HUMAN] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.[1]

About this Structure

4cml is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P. Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases. Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254 doi:http://dx.doi.org/10.1016/j.str.2014.01.013
  1. ↑ Jefferson AB, Majerus PW. Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem. 1995 Apr 21;270(16):9370-7. PMID:7721860

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