4bhd

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'''Unreleased structure'''
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{{STRUCTURE_4bhd| PDB=4bhd | SCENE= }}
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===Methanococcus jannaschii serine hydroxymethyl-transferase, apo form===
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The entry 4bhd is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GLYA_METJA GLYA_METJA]] Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo-beta-phenylserine.<ref>PMID:12902326</ref>
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Authors: Saccoccia, F., Angelucci, F., Ilari, A.
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==About this Structure==
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[[4bhd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHD OCA].
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Description: Methanococcus jannaschii serine hydroxymethyl-transferase, apo form
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Angelucci, F.]]
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[[Category: Ilari, A.]]
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[[Category: Saccoccia, F.]]
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[[Category: Transferase]]

Revision as of 09:58, 16 April 2014

Template:STRUCTURE 4bhd

Contents

Methanococcus jannaschii serine hydroxymethyl-transferase, apo form

Function

[GLYA_METJA] Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo-beta-phenylserine.[1]

About this Structure

4bhd is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Angelaccio S, Chiaraluce R, Consalvi V, Buchenau B, Giangiacomo L, Bossa F, Contestabile R. Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. J Biol Chem. 2003 Oct 24;278(43):41789-97. Epub 2003 Aug 5. PMID:12902326 doi:http://dx.doi.org/10.1074/jbc.M306747200

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OCA

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