4o64

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'''Unreleased structure'''
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{{STRUCTURE_4o64| PDB=4o64 | SCENE= }}
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===Zinc fingers of KDM2B===
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The entry 4o64 is ON HOLD until May 23 2015
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==Function==
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[[http://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN]] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref>
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Authors: Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith,C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4o64]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA].
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Description: Zinc fingers of KDM2B
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith,C H.]]
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[[Category: Bountra, C.]]
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[[Category: Edwards, A M.]]
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[[Category: Liu, K.]]
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[[Category: Min, J.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel, W.]]
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[[Category: Walker, J R.]]
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[[Category: Xu, C.]]
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[[Category: Cxxc zinc finger]]
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[[Category: Metal binding protein]]
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[[Category: Ring zinc finger]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]

Revision as of 10:08, 16 April 2014

Template:STRUCTURE 4o64

Contents

Zinc fingers of KDM2B

Function

[KDM2B_HUMAN] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.[1] [2]

About this Structure

4o64 is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006 Feb 16;439(7078):811-6. Epub 2005 Dec 18. PMID:16362057 doi:http://dx.doi.org/nature04433
  2. ↑ Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature. 2007 Nov 8;450(7167):309-13. PMID:17994099 doi:http://dx.doi.org/nature06255

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