1fhe

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[[Image:1fhe.png|left|200px]]
 
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{{STRUCTURE_1fhe| PDB=1fhe | SCENE= }}
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===GLUTATHIONE TRANSFERASE (FH47) FROM FASCIOLA HEPATICA===
===GLUTATHIONE TRANSFERASE (FH47) FROM FASCIOLA HEPATICA===
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{{ABSTRACT_PUBMED_9367777}}
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==Function==
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[[http://www.uniprot.org/uniprot/GST27_FASHE GST27_FASHE]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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{{ABSTRACT_PUBMED_9367777}}
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==About this Structure==
==About this Structure==
[[1fhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHE OCA].
[[1fhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHE OCA].
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==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:009367777</ref><references group="xtra"/>
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<ref group="xtra">PMID:009367777</ref><references group="xtra"/><references/>
[[Category: Fasciola hepatica]]
[[Category: Fasciola hepatica]]
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]

Revision as of 10:32, 16 April 2014

Template:STRUCTURE 1fhe

Contents

GLUTATHIONE TRANSFERASE (FH47) FROM FASCIOLA HEPATICA

Template:ABSTRACT PUBMED 9367777

Function

[GST27_FASHE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

About this Structure

1fhe is a 1 chain structure with sequence from Fasciola hepatica. Full crystallographic information is available from OCA.

See Also

Reference

  • Rossjohn J, Feil SC, Wilce MC, Sexton JL, Spithill TW, Parker MW. Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase. J Mol Biol. 1997 Nov 7;273(4):857-72. PMID:9367777 doi:10.1006/jmbi.1997.1338

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