1j86

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[[Image:1j86.png|left|200px]]
 
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{{STRUCTURE_1j86| PDB=1j86 | SCENE= }}
{{STRUCTURE_1j86| PDB=1j86 | SCENE= }}
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===HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2===
===HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2===
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{{ABSTRACT_PUBMED_11531339}}
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==Function==
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[[http://www.uniprot.org/uniprot/FCERA_HUMAN FCERA_HUMAN]] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
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{{ABSTRACT_PUBMED_11531339}}
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==About this Structure==
==About this Structure==
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1J86 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J86 OCA].
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[[1j86]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J86 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:11531339</ref><references group="xtra"/>
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<ref group="xtra">PMID:011531339</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Garman, S C.]]
[[Category: Garman, S C.]]
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[[Category: Ige receptor]]
[[Category: Ige receptor]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:07:19 2009''
 

Revision as of 10:41, 16 April 2014

Template:STRUCTURE 1j86

Contents

HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2

Template:ABSTRACT PUBMED 11531339

Function

[FCERA_HUMAN] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

About this Structure

1j86 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Garman SC, Sechi S, Kinet JP, Jardetzky TS. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. J Mol Biol. 2001 Aug 31;311(5):1049-62. PMID:11531339 doi:10.1006/jmbi.2001.4929

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