1p9y
From Proteopedia
(Difference between revisions)
m (Protected "1p9y" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1p9y.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_1p9y", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_1p9y| PDB=1p9y | SCENE= }} | {{STRUCTURE_1p9y| PDB=1p9y | SCENE= }} | ||
| - | |||
===Ribosome binding of E. coli Trigger Factor mutant F44L.=== | ===Ribosome binding of E. coli Trigger Factor mutant F44L.=== | ||
| + | {{ABSTRACT_PUBMED_14656439}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/TIG_ECOLI TIG_ECOLI]] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.<ref>PMID:8633085</ref> <ref>PMID:8521806</ref> <ref>PMID:14726952</ref> | |
| - | + | ||
| - | + | ||
| - | --> | + | |
| - | + | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1p9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1p9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9Y OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:014656439</ref><references group="xtra"/> | + | <ref group="xtra">PMID:014656439</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Bacillus coli migula 1895]] |
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
[[Category: Gajhede, M.]] | [[Category: Gajhede, M.]] | ||
Revision as of 10:42, 16 April 2014
Contents |
Ribosome binding of E. coli Trigger Factor mutant F44L.
Template:ABSTRACT PUBMED 14656439
Function
[TIG_ECOLI] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.[1] [2] [3]
About this Structure
1p9y is a 2 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA.
Reference
- Kristensen O, Gajhede M. Chaperone binding at the ribosomal exit tunnel. Structure. 2003 Dec;11(12):1547-56. PMID:14656439
- ↑ Hesterkamp T, Hauser S, Lutcke H, Bukau B. Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4437-41. PMID:8633085
- ↑ Valent QA, Kendall DA, High S, Kusters R, Oudega B, Luirink J. Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides. EMBO J. 1995 Nov 15;14(22):5494-505. PMID:8521806
- ↑ Genevaux P, Keppel F, Schwager F, Langendijk-Genevaux PS, Hartl FU, Georgopoulos C. In vivo analysis of the overlapping functions of DnaK and trigger factor. EMBO Rep. 2004 Feb;5(2):195-200. Epub 2004 Jan 9. PMID:14726952 doi:10.1038/sj.embor.7400067
