1ri1

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[[Image:1ri1.png|left|200px]]
 
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{{STRUCTURE_1ri1| PDB=1ri1 | SCENE= }}
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===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase===
===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase===
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{{ABSTRACT_PUBMED_14731396}}
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==Function==
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[[http://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref>
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{{ABSTRACT_PUBMED_14731396}}
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==About this Structure==
==About this Structure==
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[[1ri1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. The January 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI1 OCA].
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[[1ri1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enccn Enccn]. The January 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI1 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:014731396</ref><references group="xtra"/>
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<ref group="xtra">PMID:014731396</ref><references group="xtra"/><references/>
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[[Category: Encephalitozoon cuniculi]]
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[[Category: Enccn]]
[[Category: Messenger RNA Capping]]
[[Category: Messenger RNA Capping]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]

Revision as of 10:48, 16 April 2014

Template:STRUCTURE 1ri1

Contents

Structure and mechanism of mRNA cap (guanine N-7) methyltransferase

Template:ABSTRACT PUBMED 14731396

Function

[MCES_ENCCU] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.[1]

About this Structure

1ri1 is a 1 chain structure with sequence from Enccn. The January 2012 RCSB PDB Molecule of the Month feature on Messenger RNA Capping by David Goodsell is 10.2210/rcsb_pdb/mom_2012_1. Full crystallographic information is available from OCA.

Reference

  • Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396
  1. ↑ Hausmann S, Zheng S, Fabrega C, Schneller SW, Lima CD, Shuman S. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J Biol Chem. 2005 May 27;280(21):20404-12. Epub 2005 Mar 9. PMID:15760890 doi:10.1074/jbc.M501073200

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