1p33
From Proteopedia
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{{STRUCTURE_1p33| PDB=1p33 | SCENE= }} | {{STRUCTURE_1p33| PDB=1p33 | SCENE= }} | ||
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===Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX=== | ===Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX=== | ||
| + | {{ABSTRACT_PUBMED_12925782}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/PTR1_LEITA PTR1_LEITA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX). | |
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==About this Structure== | ==About this Structure== | ||
[[1p33]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_tarentolae Leishmania tarentolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P33 OCA]. | [[1p33]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_tarentolae Leishmania tarentolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P33 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Pteridine reductase|Pteridine reductase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012925782</ref><references group="xtra"/> | + | <ref group="xtra">PMID:012925782</ref><references group="xtra"/><references/> |
[[Category: Leishmania tarentolae]] | [[Category: Leishmania tarentolae]] | ||
[[Category: Pteridine reductase]] | [[Category: Pteridine reductase]] | ||
Revision as of 11:06, 16 April 2014
Contents |
Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX
Template:ABSTRACT PUBMED 12925782
Function
[PTR1_LEITA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
About this Structure
1p33 is a 4 chain structure with sequence from Leishmania tarentolae. Full crystallographic information is available from OCA.
See Also
Reference
- Zhao H, Bray T, Ouellette M, Zhao M, Ferre RA, Matthews D, Whiteley JM, Varughese KI. Structure of pteridine reductase (PTR1) from Leishmania tarentolae. Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1539-44. Epub 2003, Aug 19. PMID:12925782
