1pvj
From Proteopedia
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{{STRUCTURE_1pvj| PDB=1pvj | SCENE= }} | {{STRUCTURE_1pvj| PDB=1pvj | SCENE= }} | ||
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===Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex=== | ===Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SPEB_STRPY SPEB_STRPY]] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:9864206</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[1pvj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVJ OCA]. | [[1pvj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVJ OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
[[Category: Streptopain]] | [[Category: Streptopain]] | ||
Revision as of 11:06, 16 April 2014
Contents |
Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex
Function
[SPEB_STRPY] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.[1]
About this Structure
1pvj is a 4 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
