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Ribonucleotide reductase
From Proteopedia
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[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | [[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | ||
| - | [[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli'' | + | [[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''<br /> |
| + | [[4n82]] – RNR – ''Streptococcus sanguinis''<br /> | ||
===RNR large subunit complex=== | ===RNR large subunit complex=== | ||
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[[1xjn]] - TmRNR + ATP-CDP<br /> | [[1xjn]] - TmRNR + ATP-CDP<br /> | ||
[[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR /> | [[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR /> | ||
| + | [[1r2f]], [[2r2f]] - StRNR R2<br /> | ||
[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR /> | [[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR /> | ||
[[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br /> | [[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br /> | ||
Revision as of 10:52, 22 April 2014
Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.
Contents |
3D Structures of Ribonucleotide reductase
Updated on 22-April-2014
Class I RNR
RNR large subunit
1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
4n82 – RNR – Streptococcus sanguinis
RNR large subunit complex
3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, 3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
3s87 - yRNR R1 + ADP + GTP
3s8a - yRNR R1 (mutant) + GTP
3tba - yRNR R1 (mutant) + GTP + ADP
3s8b - yRNR R1 + AMPPNP + CDP
3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
3rsr – yRNR + inhibitor
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP
RNR small subunit
2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2 – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
4d8f, 4d8g - CtRNR R2 + Fe + Mn
1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
2ani - CtRNR R2 (mutant) + Fe + Pb
4dr0 - RNR + Mn – Bacillus subtilis
1uzr – RNR R2 – Mycobacterium tuberculosis
3olj – hRNR M2
1jk0 – yRNR Y2+Y4
3vpm, 3vpn, 3vpo – hRNR M2 (mutant)
RNR small subunit complex
1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate
RNR small+large subunit
3uus, 4erm - EcRNR R1+ R2
4erp - EcRNR R1+ R2 + inhibitor
2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2
Class II RNR
1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP
1pem - StRNR R1 - Salmonella typhimurium
1r2f, 2r2f - StRNR R2
1peo, 1peq, 2peu - StRNR R1 + effector
1l1l – RNR (mutant) – Lactobacillus leichmannii
Class III RNR
1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
1h7b – T4RNR (mutant)
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
