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4n8m

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{{STRUCTURE_4n8m| PDB=4n8m | SCENE= }}
{{STRUCTURE_4n8m| PDB=4n8m | SCENE= }}
===Structural polymorphism in the N-terminal oligomerization domain of NPM1===
===Structural polymorphism in the N-terminal oligomerization domain of NPM1===
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{{ABSTRACT_PUBMED_24616519}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4n8m]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8M OCA].
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[[4n8m]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8M OCA].
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==Reference==
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<ref group="xtra">PMID:024616519</ref><references group="xtra"/><references/>
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[[Category: Lk3 transgenic mice]]
[[Category: Babu, M M.]]
[[Category: Babu, M M.]]
[[Category: Buljan, M.]]
[[Category: Buljan, M.]]

Revision as of 06:26, 23 April 2014

Template:STRUCTURE 4n8m

Contents

Structural polymorphism in the N-terminal oligomerization domain of NPM1

Template:ABSTRACT PUBMED 24616519

Function

[NPM_MOUSE] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity).

About this Structure

4n8m is a 5 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  • Mitrea DM, Grace CR, Buljan M, Yun MK, Pytel NJ, Satumba J, Nourse A, Park CG, Madan Babu M, White SW, Kriwacki RW. Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4466-71. doi:, 10.1073/pnas.1321007111. Epub 2014 Mar 10. PMID:24616519 doi:http://dx.doi.org/10.1073/pnas.1321007111

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