4kr7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4kr7" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4kr7| PDB=4kr7 | SCENE= }}
 +
===Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP===
 +
{{ABSTRACT_PUBMED_24705700}}
-
The entry 4kr7 is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/THII_THEMA THII_THEMA]] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
-
Authors: Neumann, P., Ficner, R., Lakomek, K.
+
==About this Structure==
 +
[[4kr7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR7 OCA].
-
Description: Crystal structure of a 4-thiouridine synthetase -RNA complex with bound ATP
+
==Reference==
 +
<ref group="xtra">PMID:024705700</ref><references group="xtra"/><references/>
 +
[[Category: TRNA sulfurtransferase]]
 +
[[Category: Ficner, R.]]
 +
[[Category: Lakomek, K.]]
 +
[[Category: Neumann, P.]]
 +
[[Category: 4-thiouridine synthesis]]
 +
[[Category: Adenylation]]
 +
[[Category: Pp-loop motif]]
 +
[[Category: Sulfurtransferase]]
 +
[[Category: Thiouridine]]
 +
[[Category: Thump domain]]
 +
[[Category: Transferase-rna complex]]
 +
[[Category: Trna modification]]

Revision as of 07:42, 23 April 2014

Template:STRUCTURE 4kr7

Contents

Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP

Template:ABSTRACT PUBMED 24705700

Function

[THII_THEMA] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).

About this Structure

4kr7 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R. Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification. Nucleic Acids Res. 2014 Apr 5. PMID:24705700 doi:http://dx.doi.org/10.1093/nar/gku249

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kr7"
Personal tools