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4mrt

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'''Unreleased structure'''
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{{STRUCTURE_4mrt| PDB=4mrt | SCENE= }}
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===Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein===
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{{ABSTRACT_PUBMED_24704508}}
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The entry 4mrt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA]] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [[http://www.uniprot.org/uniprot/SFP_BACSU SFP_BACSU]] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.<ref>PMID:8939709</ref>
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Authors: Tufar, P., Rahighi, S., Kraas, F.I., Kirchner, D.K., Loehr, F., Henrich, E., Koepke, J., Dikic, I., Guentert, P., Marahiel, M.A., Doetsch, V.
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==About this Structure==
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[[4mrt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA].
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Description: Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein
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==Reference==
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<ref group="xtra">PMID:024704508</ref><references group="xtra"/><references/>
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[[Category: Dikic, I.]]
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[[Category: Doetsch, V.]]
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[[Category: Guentert, P.]]
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[[Category: Henrich, E.]]
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[[Category: Kirchner, D K.]]
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[[Category: Koepke, J.]]
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[[Category: Kraas, F I.]]
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[[Category: Loehr, F.]]
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[[Category: Marahiel, M A.]]
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[[Category: Rahighi, S.]]
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[[Category: Tufar, P.]]
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[[Category: Pcp: aminoacyl/peptidyl carrier]]
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[[Category: Sfp: coenzyme a binding]]
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[[Category: Sfp: phosphopantetheine transferase]]
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[[Category: Transport protein-transferase complex]]

Revision as of 07:45, 23 April 2014

Template:STRUCTURE 4mrt

Contents

Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein

Template:ABSTRACT PUBMED 24704508

Function

[TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [SFP_BACSU] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.[1]

About this Structure

4mrt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tufar P, Rahighi S, Kraas FI, Kirchner DK, Lohr F, Henrich E, Kopke J, Dikic I, Guntert P, Marahiel MA, Dotsch V. Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification. Chem Biol. 2014 Apr 2. pii: S1074-5521(14)00073-8. doi:, 10.1016/j.chembiol.2014.02.014. PMID:24704508 doi:http://dx.doi.org/10.1016/j.chembiol.2014.02.014
  1. ↑ Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chem Biol. 1996 Nov;3(11):923-36. PMID:8939709

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