4mxd

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'''Unreleased structure'''
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{{STRUCTURE_4mxd| PDB=4mxd | SCENE= }}
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===1.45 angstronm crystal structure of E.coli 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH)===
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The entry 4mxd is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MENH_ECOLI MENH_ECOLI]] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.<ref>PMID:15808744</ref> <ref>PMID:18284213</ref>
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Authors: Sun, Y., Yin, S., Feng, Y., Li, J., Zhou, J., Liu, C., Zhu, G., Guo, Z.
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==About this Structure==
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[[4mxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXD OCA].
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Description: 1.45 angstronm crystal structure of E.coli 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase]]
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[[Category: Feng, Y.]]
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[[Category: Guo, Z.]]
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[[Category: Li, J.]]
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[[Category: Liu, C.]]
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[[Category: Sun, Y.]]
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[[Category: Yin, S.]]
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[[Category: Zhou, J.]]
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[[Category: Zhu, G.]]
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[[Category: 2-succinyl-6-hydroxy-2]]
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[[Category: 4-cyclohexadiene-1-carboxylate synthase]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Lyase]]
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[[Category: Open conformation]]

Revision as of 07:55, 23 April 2014

Template:STRUCTURE 4mxd

Contents

1.45 angstronm crystal structure of E.coli 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH)

Function

[MENH_ECOLI] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.[1] [2]

About this Structure

4mxd is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Kuznetsova E, Proudfoot M, Sanders SA, Reinking J, Savchenko A, Arrowsmith CH, Edwards AM, Yakunin AF. Enzyme genomics: Application of general enzymatic screens to discover new enzymes. FEMS Microbiol Rev. 2005 Apr;29(2):263-79. PMID:15808744 doi:S0168-6445(05)00004-5
  2. ↑ Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z. Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry. 2008 Mar 18;47(11):3426-34. doi: 10.1021/bi7023755. Epub 2008 Feb, 20. PMID:18284213 doi:10.1021/bi7023755

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