2d5g

From Proteopedia

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Revision as of 08:18, 23 April 2014

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Template:STRUCTURE 2d5g

Contents 1 Structure of ubiquitin fold protein R767E mutant 2 Function 3 About this Structure 4 See Also

Structure of ubiquitin fold protein R767E mutant

Function

[AXN1_RAT] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).

About this Structure

2d5g is a 6 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

See Also

• Axin